SYNTHETIC OLIGONUCLEOTIDES WHICH MIMIC TELOMERIC SEQUENCES

摘要

A method of inhibiting proliferation of cancer and other immortal type cellular disease states is disclosed. The method includes introduction of synthetic oligonucleotides which mimic telomere motifs. Quite surprisingly applicant has demontrated that a single telomere motif, TTAGGG exhibits greater cellular uptake and higher inhibition of proliferation than longer oligonucleotides, which were previously thought to be necessary to achieve sequence specific interaction with telomerase.