摘要 |
The invention relates to a novel diffusion-osmotic controlled drug-release pharmaceutical composition containing a one-layer tablet core including a polymeric film-coat, a therapeutically active agent and a hydrophilic polymer; if desired, a two-layer tablet core including active agent and hydrophilic polymer in the first layer thereof and a hydrophilic polymer in the second layer thereof; at least one bore on the part of film-coat in contact with the core or core layer containing the active agent; and, if desired, containing one or more bore(s) in the part thereof in contact with the second layer containing the hydrophilic polymer, which comprises an ammonium methacrylate copolymer as coating material and hydroxypropyl-methylcellulose as hydrophilic polymer. The composition according to the invention is useful for preparing controlled drug-release tablets containing as active agents e.g. beta -adrenergic inhibitors (e.g. propranolol) calcium-antagonists (e.g. nifedipine), angiotensin convertase enzyme (ACE) inhibitors (e.g. captopril); prazosin; or nitroglycerol, all used in heart and circulation diseases; vasodilatory active agents (e.g. pentoxyfylline), nonsteroidal antiinflammatory agents (e.g. naproxene), analgetic drugs (e.g. morphine) and drugs acting on the central nervous system (e.g. amitriptyline, buspiron). The invention furthermore relates to a process for the preparation of the above compositions.
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申请人 |
EGIS GYOGYSZERGYAR RT. |
发明人 |
FEKETE, P+E,ACU A+EE L;KIR+E,ACU A+EE LY N+E,ACU E+EE E IGN+E,ACU A+EE CZ, M+E,ACU A+EE RIA;SIPOS, G+E,ACU A+EE BOR;J+E,ACU A+EE MBOR N+E,ACU E+EE E HOFFMANN, ZSUZSANNA;+E,ACU U+EE JFALUSSY, GY+E,UML O+EE RGY;G+E,ACU O+EE RA N+E,ACU E+EE E HERNYES, MAGDOLNA;KLEBOVICH, IMRE;DRABANT, S+E,ACU A+EE NDOR;M+E,ACU A+EE NDI, ATTILA;KISS N+E,ACU E+EE E SZAB+E,ACU O+EE , GIZELLA;B+E,ACU A+EE RCZAY, ERZS+E,ACU E+EE BET;KRISZTI+E,ACU A+EE N, M+E,ACU A+EE RIA |