发明名称 |
Sphingosomes for enhanced drug delivery |
摘要 |
Liposomal formulations having extended circulation time in vivo and increased drug retention are comprised of sphingomyelin and cholesterol and have an acidic intraliposomal pH. The formulations have enhanced stability and thus are used in methods which provide improved drug delivery and more effective treatment. The delivery of lipophilic drugs such as the vinca alkaloids, and particularly vincristine and vinblastine, to tumors is significantly improved.
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申请公布号 |
US5543152(A) |
申请公布日期 |
1996.08.06 |
申请号 |
US19940263603 |
申请日期 |
1994.06.20 |
申请人 |
INEX PHARMACEUTICALS CORPORATION |
发明人 |
WEBB, MURRAY S.;BALLY, MARCEL B.;MAYER, LAWRENCE D. |
分类号 |
A61K9/127;A61K47/24;A61K47/28;(IPC1-7):A61K9/127;A61K31/44 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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