Achiral amino acid acyl esters of ganciclovir and its derivatives

摘要

Compounds of the Formula I <IMAGE> wherein X is hydrogen, chloro, amino or hydroxy; R1 is an achiral amino acid acyl residue with a tertiary alpha -carbon atom. Preferred achiral amino acid acyl residues have the formula <IMAGE> wherein each R2 is alkyl with 1 to 6 carbon atoms, cycloalkyl with 3 to 5 carbon atoms, or benzyl; or the two R2 groups link together to form a polymethylene group with 3 to 9 carbon atoms, and pharmaceutically acceptable salts thereof are antiviral agents with improved absorption. Intermediates for the preparation of the compounds of Formula I are also described.