New N-acyl dipeptides and their use

摘要

Novel N-acyl depeptides of the formula:R2-NH-CHR1-CO-ASin which AS, R1 and R2 have certain, more precisely defined meanings. These N-acyl dipeptides are more stable under conditions of sterilization (121 DEG C.) than corresponding, non-acylated dipeptides. On the other hand, they are cleaved more rapidly and more completely at the peptide bond in the living organism than the cleavage of the acyl group from simple N-acyl amino acids takes place. They can therefore be used with advantage as a source for the carbon terminal amino acid in mixtures and solutions for artificial nutrition or in culture media for cell cultures.