发明名称 |
Verfahren zur Herstellung von optisch reinen Diastereoisomeren von Tetrahydrofolatverbindungen |
摘要 |
A process for the preparation of optically pure diastereoisomers of tetrahydrofolate compounds is described, comprising the conversion, for example, of only the 5,6S,7,8-tetrahydrofolic acid component of a racemic mixture of 5,6,7,8-tetrahydrofolic acid to 10-formyl-5,6S,7,8-tetrahydrofolic acid in the presence of a formyl tetrahydrofolate synthetase, followed by cyclizing, hydrolyzing and derivatizing. The process is also useful to make a desired substantially pure (6R or 6S) enantiomer of a derivative or (radiolabeled) tetrahydrofolic acid or a salt or ester thereof. |
申请公布号 |
DE69027585(D1) |
申请公布日期 |
1996.08.01 |
申请号 |
DE1990627585 |
申请日期 |
1990.11.05 |
申请人 |
AMERICAN CYANAMID CO., WAYNE, N.J., US |
发明人 |
SCHLINGMANN, GERHARD, HILBURN, NY 10931, US;ROSENFELD, STUART ALAN, ALAMEDA, CA 94501, US |
分类号 |
C07D475/04;C12N9/00;C12P17/18;C12P41/00 |
主分类号 |
C07D475/04 |
代理机构 |
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代理人 |
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