发明名称 |
MULTIPLE COMPONENT RNA CATALYSTS AND USES THEREOF |
摘要 |
This invention is directed to a composition for catalyzed oligonucleotide cleavage comprising a synthetic non-naturally occurring oligonucleotide compound. The compound comprises nucleotides whose sequence defines a conserved group II intron catalytic region and nucleotides whose sequence is capable of hybridizing with a predetermined oligonucleotide target sequence to be cleaved, such target sequence not being present within the compound. The composition also includes an appropriate oligonucleotide co-factor. Preferably, the conserved group II intron catalytic region is a group II intron domain I catalytic region. In one embodiment the conserved group II intron domain I catalytic region may further comprise a conserved portion of a group II intron domain II, a group II intron domain III, a group II intron domain IV, a group II intron domain V, or a group II intron domain VI. The invention is also directed to methods of treatment and methods of use of such compounds.
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申请公布号 |
WO9622689(A1) |
申请公布日期 |
1996.08.01 |
申请号 |
WO1996US01337 |
申请日期 |
1996.01.25 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF;PYLE, ANNA, M.;MICHELS, WILLIAM, J. |
发明人 |
PYLE, ANNA, M.;MICHELS, WILLIAM, J. |
分类号 |
A01K67/027;A61K38/00;C12N15/113;(IPC1-7):A01N43/04;A01N63/00;A61K31/70;A61K48/00;C12N1/00;C12N5/00;C12N5/06;C12N5/10;C12N15/00;C12N15/09;C12N15/11 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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