SUSTAINED-RELEASE PREPARATION AND USE

摘要

This invention provides a sustained-release preparation production method comprising production of a W/O emulsion whose internal aqueous phase is a solution containing a bioactive peptide represented by formula (I), wherein X represents a hydrogen atom or a tetrahydrofurylcarboxamido; Q represents a hydrogen atom or methyl; A represents nicotinoyl or N,N'-diethylamidino; B represents isopropyl or N,N'-diethylamidino, or a salt thereof, and whose oil phase is a solution containing a biodegradable polymer having a free carboxyl group at one end, and adding the W/O emulsion into an external water phase to produce W/O/W emulsion. According to the production method of the present invention, a sustained-release preparation containing peptide (I) or a salt thereof can be obtained easily and at high recovery rates.