发明名称 |
IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS S-ADENOSYLMETHIONINE DECARBOXYLASE (=SAMDC) INHIBITORS |
摘要 |
Described are compounds of formula (I), wherein R1 is hydrogen or hydroxy; R2, R2' and R2" are each independently of the others hydrogen or a substituent other than hydrogen; either R3 is hydrogen or a substituent other than hydrogen and R4 is hydrogen or lower alkyl, or R3 and R4 together form a divalent radical of the formula -(CH2)n- wherein n is 2 or 3; R5 and R6 are each indenpendently of the other hydrogen, alkyl or aryl; and either R7 and R8 are each hydrogen, or R7 and R8 together form a bond; tautomers thereof, provided that at least one tautomerisable group is present; and salts thereof. The compounds inhibit the enzyme S-adenosylmethionine decarboxylase and are suitable, for example, for the treatment of tumors and protozoal infections.
|
申请公布号 |
WO9622979(A1) |
申请公布日期 |
1996.08.01 |
申请号 |
WO1996EP00143 |
申请日期 |
1996.01.15 |
申请人 |
CIBA-GEIGY AG;FREI, JOERG;STANEK, JAROSLAV |
发明人 |
FREI, JOERG;STANEK, JAROSLAV |
分类号 |
A61K31/415;A61P33/02;A61P35/00;A61P43/00;C07D233/46;C07D233/88;(IPC1-7):C07D233/88 |
主分类号 |
A61K31/415 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|