发明名称 |
METHODS OF ENHANCING THE THERAPEUTIC ACTIVITY OF NSAIDS AND COMPOSITIONS OF ZWITTERIONIC PHOSPHOLIPIDS USEFUL THEREIN |
摘要 |
Disclosed are compositions comprising non-steroid anti-inflammatory drugs (NSAID's) complexed with zwitterionic, neutral phospholipids, or both, having reduced gastrointestinal irritating effects and enhanced anti-pyretic, analgesic, and anti-inflammatory activity. Also disclosed are improved methods of using the complexes for treating fever, inflammation, and preventing platelet aggregation. In some embodiments, the anti-pyretic activity of sub-therapeutically used amounts of NSAID's are enhanced to elicit anti-pyretic activity in vivo when associated (noncovalently) with zwitterionic phospholipids, such as dipalmitoyl phosphatidyl choline.
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申请公布号 |
WO9622780(A1) |
申请公布日期 |
1996.08.01 |
申请号 |
WO1996US00633 |
申请日期 |
1996.01.24 |
申请人 |
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SY |
发明人 |
LICHTENBERGER, LENARD, M.;BUTLER, BRUCE, D. |
分类号 |
A61K31/19;A61K31/192;A61K31/195;A61K31/196;A61K31/405;A61K31/60;A61K31/66;A61K31/74;(IPC1-7):A61K31/74 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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