摘要 |
Synthetic peptides which have the sequence: Q<1>-CO-Ala<2>-Asp<3>-Ala<4>-Ile<5>-Phe<6>-Thr<7>-R<8>-Ser<9>-Tyr<10>-Arg<11>-R<12>-Val<13>-Leu<14>-R<15>-Gln<16>-Leu<17>-Ser<18>-Ala<19>-Arg<20>-R<21>-Leu<22>-Leu<23>-Gln<24>-Asp<25>-Ile<26>-R<27>-R<28>-NH-Q<2> wherein Q<1> is an omega or alpha-omega substituted alkyl of structure (I), where: [ PHI ] is phenyl; Y is H, -NH2, CH3CONH- or CH3NH-; Z is H or CH3; m is 1 or 2; n is 0, 1 or 2; R<8> is Asn, Ser, Gln or Thr; R<12> is Lys or Orn; R<15> is Gly, Ala, or Abu; R<21> is Lys or Orn; R<27> is Met or Nle; R<28> is Ser or Asp; and Q<2> is a lower omega-guanidino-alkyl group having a formula: -(CH2)p-NH-C(NH2) = NH wherein p is 2-6, and the pharmaceutically acceptable addition salts thereof with the pharmaceutically acceptable organic or inorganic bases or acids.
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