ANTI-MOTONEURON-DISEASE AGENT

摘要

The present invention relates to an novel antimotoneuron-disease agent, comprising superoxide dismutase conjugated with lecithin through chemical crosslinking represented in the following generic formula (PC-SOD) as an effective ingredient: SOD-¢C(O)-(CH2)n-C(O)-X!m , wherein SOD represents superoxide dismutase and X represents a residue of lysolecithin having a hydroxy group at position 2 of glycerol whose hydrogen atom of the hydroxyl group at position 2 is removed. A pharmaceutical agent of the present invention may improve symptoms of motoneuron diseases such as amyotrophic lateral sclerosis etc. by oral or parenteral administration. The present invention also relates to a novel treatment method for motoneuron disease by administrating PC-SOD and novel use of PC-SOD as a medical composition for preparing an agent for treating motoneuron disease.