IMMUNOLOGICAL PURGING OF TUMOR CELLS FROM BONE MARROW USING MICROSPHERES AND MONOCLONAL ANTIBODIES.

摘要

A method is described for the immunological purging of tumor cells from the bone marrow of a patient having B cell lymphoma. The purged bone marrow may be used for therapeutic autologous bone marrow transplantation. Microspheres and a plurality of anti-B cell monoclonal antibodies are used to remove tumor cells from bone marrow, without removal or lysis of non-tumor cells, to a level not detectable by polymerase chain reaction assay.