| 摘要 |
According to one aspect of the invention there is provided a transgenic animal which is heterozygous for an at least partially defective thyroid hormone receptor gene. The defective gene may be inactivated for example by an insertion, deletion, substitution or inversion or other suitable genetic manipulation. According to other aspects of the invention there are provided cells derived from the transgenic mammal of the invention and methods of testing the agonist/antagonist properties of a compound using the transgenic mammal of the invention or such cells. |
