Heterocycle-substituted benzenemethanamine derivatives

摘要

The present invention is concerned with antiretroviral (e.g. anti-HIV-1) compounds having the formula <IMAGE> (I) wherein R1 and R2 each independently are halo or methyl; R3 is hydrogen, halo, nitro or trifluoromethyl; R4 is trifluoromethyl or methylcarbonyl; or a radical -C(=X)-NR5R6 wherein X is O or S, and R5 and R6 each independently are hydrogen or C1-4alkyl; or a radical -Alk-R7, wherein Alk is C1-4alkanediyl; and R7 is hydrogen or hydroxy; Het is a heterocyclic radical of formula: GE> (d) <IMAGE> (e) Pharmaceutical compositions containing said compounds of formula (I) and processes of preparing said compounds and compositions.