摘要 |
<p>The present invention provides an antiproliferative p-heteroatom-substituted phenol compound having structure formula (I), wherein m is 0 to 3, n is 0 when Het is oxygen or sulfur, 0 to 4 when Het is nitrogen, Het is nitrogen, oxygen or sulfur; wherein R is selected from the group consisting of hydrogen, alkyl, arylmethyl and acyl; R1 is alkyl; R2 is selected from the group consisting of hydrogen and alkyl; R3 is selected from the group consisting of alkyl and acyl when Het is nitrogen, : (electron pair) when Het is oxygen or sulfur; R4 is selected from the group consisting of hydrogen and alkyl; R5 is selected from the group consisting of hydrogen and alkyl; and R?6 and R7¿ are selected from the group consisting of hydrogen, alkyl and oxygen. Also provided are various methods for the treatment of a pathological cell proliferative disease comprising administering to an animal a pharmacologically and therapeutically effective dose of a pharmaceutical composition comprising a p-heteroatom-substituted phenols or an analog thereof.</p> |