| 摘要 |
Compounds that exhibit selectin binding activity are described and have the following structural formula: <IMAGE> where W is selected from a group including structures a-d below <IMAGE> (a) <IMAGE> (b) <IMAGE> (c) <IMAGE> (d) wherein p is an integer of from 0-2, q is an integer of from 0-3, and r is an integer of from 0-5; A is selected from the group consisting of alpha and beta forms of sialic acid, Kemp's acid, quinic acid, R and S forms of mandelic acid, R and S forms of glyceric acid, R and S forms of lactic acid, propionic and acetic acid, and esters and amides thereof, -SO3, sulfonate, -PO3, phosphonate, trifluoromethyl, diazine and triazine; B is selected from a group consisting of alpha and beta forms of fucose, arabinose and esters and substituted forms thereof wherein one or more of the OH groups is independently substituted with F, N3, NHAc, NHCOCF3. The remaining variable are described in the specification. |
