| 摘要 |
<p>The inventions disclosed are new members of the steroid receptor superfamily of receptors of which a representative member has been designated XOR-6. The receptors are responsive to hydroxy, mercapto or aminobenzoates and are expressed in Xenopus leavis embryos. XOR-6 is most closely related to the vitamin D3 receptor. The amino acid sequences are about 73 % identical in the DNA-binding domains and about 42 % identical in the ligand binding domain. Like the vitamin D3 receptor, XOR-6 has an extended D region between the DNA and ligand binding domains. The region amino-terminal to the XOR-6 DNA-binding domain is extremely acidic which may influence its ability to activate genes. Southern blots show that XOR-6 related sequences are present in other vertebrates including humans. Also disclosed are nucleotide sequences encoding the XOR-6 receptor, constructs and cells containing sane, and probes derived from the XOR-6 sequence. Hydroxy, mercapto and aminobenzoates modulate the transcription of the invention receptors.</p> |
