NOVEL FARNESYL TRANSFERASE INHIBITORS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

摘要

Novel farnesyl transferase inhibitors of general formula (I), preparation thereof and pharmaceutical compositions containing same. In general formula (I), R1 is Y-S-A1 (where Y is a hydrogen atom, an amino acid residue, a fatty acid residue, or an alkyl or alkoxycarbonyl radical, and A1 is a C1-4 alkylene radical optionally alpha -substituted in the >C(X1)(Y1) grouping by an amino, alkylamino, alkanoylamino or alkoxycarbonylamino radical wherein the alkyl or alkanoyl portion contains 1-6 carbon atoms; each of X1 and Y1 is a hydrogen atom or X1 and Y1, taken together with the carbon atom to which they are attached, form a >C=O grouping; R'1 is hydrogen or a C1-6 alkyl radical; X is an oxygen or sulphur atom; R2 is a C1-6 alkyl, alkenyl or alkynyl radical optionally substituted by hydroxy, alkoxy, mercapto, alkylthio, alkylsulphinyl or alkylsulphonyl, with the proviso that when R2 is an alkyl radical substituted by a hydroxy radical, then R2 and the alpha carboxy radical can form a lactone; R'2 is hydrogen or a C1-6 alkyl radical; and R is a hydrogen atom, an optionally substituted alkyl radical or an optionally substituted phenyl radical. Said novel products have anticancer properties.