Retrovirus-like particles made non-infectious by aplurality of mutations
摘要
Non-infectious, retrovirus-like particles contain mutations to reduce gag-dependent RNA-packaging of the gag gene product, eliminate reverse transcriptase activity of the pol gene product, eliminate integrase activity of the pol gene product and eliminate RNase H activity of the pol gene product through genetic manipulation of the gag and pol genes. The corresponding nucleic acid molecules are described. The non-infectious, retrovirus-like particles have utility in in vivo administration including to humans and in diagnosis.
申请公布号
WO9606177(A3)
申请公布日期
1996.07.25
申请号
WO1995CA00489
申请日期
1995.08.22
申请人
CONNAUGHT LABORATORIES LIMITED;ROVINSKI, BENJAMIN;CAO, SHI-XIAN;YAO, FEI-LONG;PERSSON, ROY;KLEIN, MICHAEL, H.
发明人
ROVINSKI, BENJAMIN;CAO, SHI-XIAN;YAO, FEI-LONG;PERSSON, ROY;KLEIN, MICHEL, H.