发明名称 |
Peptides specific for the first crk-sh3 domain |
摘要 |
The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography. |
申请公布号 |
AU4743496(A) |
申请公布日期 |
1996.07.24 |
申请号 |
AU19960047434 |
申请日期 |
1995.12.28 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
HIDESABURO HANAFUSA;BEATRICE S KNUDSEN;STEPHAN M FELLER;JOHN KURIYAN;XIAODONG WU;JIE ZHENG;DAVID COWBURN |
分类号 |
A61K38/00;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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