INCLUSION COMPLEXES OF N-ETHOXYCARBONYL-3-MORPHOLINO- SYDNONIMINE OR SALTS FORMED WITH CYCLODEXTRIN-DERIVATIVES, PREPARATION THEREOF ANDPHARMACEUTICAL COMPOSITIONS CONTAINING THESAME

摘要

The invention relates to inclusion complexes of Nethoxycarbonyl-3-morpholino-sydnonimine or its salts formed with a cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same. The inclusion complex of N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared by a) reacting the N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt and the cyclodextrin derivative in a solvent medium, and if desired recovering the complex from the solution by dehydratation, or b) high energy milling of the N-ethoxycarbonyl-3-morpholino-sydnonimine or its salt and the cyclodextrin derivative.