New mandelic acid derivatives and their use as thrombin inhibitors

摘要

There is provided a compound of formula (I) wherein R^a, R¹, R², Y and R³ have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g., thrombosis) or as anticoagulants.