摘要 |
Disclosed are compounds of Formula I: <IMAGE> (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: R3 is alkyl, alkenyl, alkynyl, aryl, alkaryl, aralkyl, cycloalkyl, acyloxymethyl, alkoxy, alkoxymethyl, or alkyl substituted with cycloalkyl; R4 is H, alkyl, alkenyl, alkoxy, or -OH. Also disclosed are pharmaceutical compositions containing compounds of Formula I, methods for inhibiting tumor necrosis factor- alpha and methods for treating septic shock, inflammation, or allergic disease by administering a compound of Formula I.
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申请人 |
SCHERING CORPORATION |
发明人 |
TING, PAULINE C.;SOLOMON, DANIEL M.;FRIARY, RICHARD J.;VILLANI, FRANK J.;PIWINSKI, JOHN J.;LEE, JOE F.;VASHI, DHIRU B. |