| 摘要 |
PCT No. PCT/EP95/05173 Sec. 371 Date Jun. 16, 1997 Sec. 102(e) Date Jun. 16, 1997 PCT Filed Dec. 21, 1995 PCT Pub. No. WO96/20200 PCT Pub. Date Jul. 4, 1996This invention is concerned with the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein: R1 is hydrogen, amino or C1-4alkyl; R2 is hydrogen, halo or C1-4alkyl; R3 is hydrogen, halo or C1-4alkyl; Y is 0 or S, and -X1=X2-is a bivalent radical having the formula -N=CH-(a-1) or -CH=N-(a-2); compositions containing the same, and processes of preparing these compounds. It further relates to their use as a medicine, in particular their use as a medicine to treat keratinization disorders. |
