STEREOISOMERS OF ITRACONAZOLE OR SAPERCONAZOLE, METHOD OF THEIR SYNTHESIS, THEIR COMPLEXES AND METHOD OF PREPARING, PHARMACEUTICAL COMPOSITION ON THEIR BASE AND ITS PREPARING, METHOD OF PREPARING AQUEOUS SOLUTIONS AT INCREASED CONCENTRATION OF ITRACONAZOLE OR SAPERCONAZOLE

摘要

FIELD: organic chemistry. SUBSTANCE: invention relates to stereoisomeric forms of itraconazole (X - Cl) and saperconazole (X - F) that can be presented by formula cis-(I), given in the description, their pharmaceutically acceptable acid-additive salt forms, methods of synthesis indicated above stereoisomeric forms, their complexes with cyclodextrin derivatives, pharmaceutical compositions containing indicated above complexes and methods of preparing indicated above complexes and pharmaceutical compositions. EFFECT: improved methods of synthesis.