PROCESS FOR PREPARING β-PHENYLISOSERINE AND ANALOGS THEREOF, PROCESS FOR PREPARING TAXANE DERIVATIVES, AND INTERMEDIATE COMPOUNDS OF SYNTHESIS

摘要

FIELD: medicine. SUBSTANCE: invention relates to process for preparing b-phenylisoserine and analogs thereof of general formula (I) from aromatic aldehyde and b- methylarylamine-S with intermediate lactam of general formula (II). In formulae (I) and (II). Ar represents aryl, Ph represents phenyl optionally substituted, a is group protecting the function of alcohol in the form of ester or ether, R is hydrogen or alkyl optionally substituted by phenyl. Acids of formula (I), wherein R is H, are suitable for preparing taxane derivatives having antitumor and antileukemic properties. EFFECT: improved properties of taxane derivatives.