| 发明名称 |
CYCLIC PEPTIDE ANTIFUNGAL AGENTS AND PROCESS FOR PREPARATIONTHEREOF |
| 摘要 |
Provided are compounds of the formula (1): see formula (1) wherein R' is hydrogen, methyl or NH2C(O)CH2-; R" is methyl or hydrogen; R is hydroxy or hydrogen; R1 is hydroxy, hydrogen, or hydroxysulfonyloxy; R7 is hydroxy, hydrogen, hydroxysulfonyloxy or phosphonooxy; R2 is a novel acyl side chain. Also provided are novel formulations, methods of inhibiting fungal and parasitic activity, and a process for preparing dideoxy (R=H) forms of the compounds.
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| 申请公布号 |
CA2091663(C) |
申请公布日期 |
2007.10.30 |
| 申请号 |
CA19932091663 |
申请日期 |
1993.03.15 |
| 申请人 |
ELI LILLY AND COMPANY |
发明人 |
BURKHARDT, FREDERICK JOSEPH;DEBONO, MANUEL;NISSEN, JEFFREY SCOTT;TURNER, WILLIAM WILSON, JR. |
| 分类号 |
A61K38/00;C07K7/56;A01N43/90;A61K38/12;A61P31/04;A61P31/10;C07F9/6561;C07K;C07K1/02;C07K1/113;C07K7/06;C07K7/54;C07K7/64;C07K14/41 |
主分类号 |
A61K38/00 |
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