Polymeric supports

摘要

Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct supports. The adduct supports are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer supports, are intermediates in the preparation of the azlactone-functional supports. Azlactone-functional supports have units of the formula: wherein R<1> is H or CH3, R<2> and R<3> independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic 0 heteroatoms, or R<2> and R<3> taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, and n is an integer 0 or 1, the azlactone functional supports, which can be membranes, films, or coatings on a substrate, having 0 to 99 molar parts of crosslinking monomer incorporated therein, or beads, having 0 to 5 molar parts of crosslinking monomer incorporated therein.