| 摘要 |
FIELD: organic chemistry, medicine, biochemistry, pharmacy. ^ SUBSTANCE: invention relates to novel derivatives of indoline of the formula (I): wherein (i) R1 means hydrogen atom (H), (C1-C4)-alkyl; R2 means -A1-NR5R6 wherein each substitute R5 and R6 means independently H, (C1-C4)-alkyl; A1 means -(CH2)m, -(CH2)n-A2-(CH2)p or -(CH2CH2O)qCH2CH2 wherein m means a whole number from 2 to 10; each n and p means a whole number from 1 to 6; A2 means -CH=CH, phenylene, biphenylene, cyclohexylene or piperazinylene; q = 1, 2 or 3; (ii) R1 and R2 represent in common -A3-NR7-A4 wherein each A3 and A4 means independently -(CH2)r or -(CH2CH2O)sCH2CH2 wherein r means a whole number from 2 to 6; s = 1, 2 or 3; R7 means H, (C1-C4)-alkyl; (iii) R1 and R2 in common with nitrogen atom to which they are bound form piperidinyl that comprises a substitute of the formula: -A5-R8 at 4 position wherein A5 represents (C1-C4)-alkylene, and R8 represents piperidin-4-yl; or (iv) R1 and R2 in common with nitrogen atom to which they are bound form piperidinyl, and each R3 and R4 means independently H, or its pharmaceutically acceptable salt. Proposed compounds inhibit tyrosine kinase receptors that allow their using as components of pharmaceutical compositions for treatment. Also, invention describes methods for synthesis of compounds of the formula (I). ^ EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical compositions. ^ 15 cl, 1 tbl, 24 ex |
