发明名称 |
Process for P-nitrobenzyl ester cleavage in cephalosporin |
摘要 |
A process for converting cephalosporin p-nitrobenzyl ester (Formula I) to the corresponding cephalosporin free acid (Formula II) comprising treating the cephalosporin p-nitrobenzyl ester with a metal selected from the group consisting of iron, magnesium, aluminum, and tin, and with hydrochloric acid in a mixture of water and a water-miscible organic solvent. Preferably, the metal is iron in the form of a fine powder, and the reaction is carried out at a temperature in the range of 30 DEG -50 DEG C.
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申请公布号 |
US5536830(A) |
申请公布日期 |
1996.07.16 |
申请号 |
US19950453911 |
申请日期 |
1995.05.30 |
申请人 |
RANBAXY LABORATORIES, LTD. |
发明人 |
KHANNA, JAG M.;KUMAR, YATENDRA;ARORA, RAKESH K.;TIWARI, NEERA;SINGH, SHAILENDRA K. |
分类号 |
C07D501/00;C07D501/04;(IPC1-7):C07D501/04 |
主分类号 |
C07D501/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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