Integrin-binding peptides

摘要

The present invention provides peptides having specificity for fibronectin-binding and vitronectin-binding integrins, and in particular for alpha 5 beta 1 integrin. These peptides are characterized by having the ability to interfere with extracellular matrix protein binding to integrins; to block attachment of cells expressing these integrins to extracellular matrix proteins; and to promote cell attachment when coated onto a surface.