DIRECT ADMINISTRATION OF GENE DELIVERY VEHICLES AT MULTIPLE SITES

摘要

Methods of stimulating an immune response, either humoral or cell-mediated, in a warm-blooded animal through the administration at multiple sites of one or more gene delivery vehicles is provided. Each of the gene delivery vehicles directs the expression of at least one substance in host cells modified with the vehicle, such that an immune response is generated. Within preferred embodiments, the expressed substance elicits a cell-mediated immune response, preferably an HLA Class I-restricted immune response.