| 摘要 |
The present invention provides peptides, therapeutic compositions, and methods for treatment of rheumatoid arthritis in mammals, specifically in humans. The peptides of the invention comprise fragments of type II collagen which bind specifically with human major histocompatibility complex proteins known to be genetically linked to susceptibility to rheumatoid arthritis. The therapeutic compositions of the invention comprise the peptides, alone or in combination with other collagen peptides. In one method of the invention, therapeutic compositions of the peptides are administered by injection, transdermally, by inhalation, or orally to a patient in need of treatment. |
