摘要 |
<p>A transdermal penetration-enhancing, drug acid-lability reducing composition and related method are described. Specifically, the transdermal composition comprises: (a) a therapeutically effective amount of a pharmacologically active drug which is subject to acid catalyzed degradation; (b) a pharmaceutically acceptable carrier substantially free of a lower alkanol; and (c) a penetration-enhancing amount of a functional derivative of a fatty acid. Such compositions increase the usefulness of transdermal compositions that rely upon an organic acid such as oleic acid penetration enhancer.</p> |