PIPERIDINE-BASED SIGMA RECEPTOR LIGANDS

摘要

Compounds of formula (I) or pharmaceutically acceptable salts therof wherein X = O, CO or CHOH; R' is fluoroalkyl of 2 to 5 carbon atoms and 1 to 11 fluorine atoms; mono- and di-substituted benzyl wherein the substituents are selected from NO2, CN, I, Br, F, OH, OCH3 or OCH2OCH3 the substituents being at the meta or para positions; iodoalkenyl groups of 3 to 6 carbon atoms; bromoalkenyl groups of 3 to 6 carbon atoms; alkyl groups of 1 to 5 carbon atoms; or hydroxyalky containing 2 to 5 carbon atoms and 1 to 3 hydroxyl groups; R' is phenyl optionally substituted with one or two groups at the meta or para positions selected from methyl, ethyl, I, Br, CN, NO2, OH, CF3, OR wherein R is phenyl, 4-cyanophenyl, 4-nitrophenyl, CF3, methyl or ethyl; iodoalkenyl of 3 to 6 carbon atoms; bromoalkenyl of 3 to 6 carbon atoms; fluoroalkyl of 1 to 5 carbon atoms and 1 to 11 fluorine atoms; or alkyl groups of 1 to 5 carbon atoms as piperidine based sigma-1 receptor ligands suitable for use in diagnosis and therapy of diseases such as psychosis and cancer.