| 摘要 |
FIELD: medicine. SUBSTANCE: claimed squalene-synthetase inhibitor comprises compound represented by formula:wherein Ris hydrogen or optionally substituted hydrocarbon group; Ris hydrogen optionally substituted alkyl group, optionally substituted phenyl group or optionally substituted aromatic heterocyclic ring; X′ is substituent containing optionally esterified carboxy group, optionally substituted carbamoyl group, optionally substituted hydroxy group, optionally substituted amino group or optionally substituted heterocyclic radical containing hydrogen being protonized; ring A represents optionally substituted benzene ring or optionally substituted aromatic heterocyclic ring; ring j′ represents 7- or 8- membered heterocyclic rings containing not more than three heteroatoms in the ring; D represents C or N; ring j′ optionally, in addition to R,, Rand X′, contains additional substituent; provided that condensed ring consisting of ring A and j′ is not 2-oxo-1,2,3,5- tetrahydro-4,1-benzoxazepine ring, or pharmaceutically acceptable salt thereof, and which may be used for the prophylaxis or therapy of hypercholesterolemia or coronary selerosis in mammals. EFFECT: improved properties of the title compounds. |
