| 发明名称 |
CD28 PATHWAY IMMUNOREGULATION. |
| 摘要 |
Use of an anti-CD28 antibody or a F(ab')2 fragment thereof in the manufacture of a medicament for administration to a population of CD3-activated CD28<+> T-cells of a patient to promote the production of a cyclosporine resistant lymphokine selected from IL-2, TNF, IFN-gamma and GM-CSF. |
| 申请公布号 |
EP0637963(A4) |
申请公布日期 |
1996.07.10 |
| 申请号 |
EP19930910570 |
申请日期 |
1993.04.06 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN;THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY |
发明人 |
THOMPSON, CRAIG, B.;JUNE, CARL, H. |
| 分类号 |
C12N15/02;A61K35/14;A61K35/28;A61K38/00;A61K38/17;A61K38/46;A61K39/395;A61P31/18;A61P37/04;C07K14/705;C07K16/00;C07K16/28;C12N5/0783;C12N5/10;C12P21/02;C12P21/08 |
主分类号 |
C12N15/02 |
| 代理机构 |
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代理人 |
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