| 摘要 |
PURPOSE: To obtain a new allergen to pollen of Chamaecyraris obtusa having a specific amino acid sequence as a T-cell epitope and a B-cell epitope and useful for diagnosis, prevention or curing, etc., of an antigen-specific pollinosis of Chamaecyraris obtusa. CONSTITUTION: This novel allergen to pollen of Chamaecyraris obtusa is composed of an allergen to pollen of Chamaecyraris obtusa Cha. o. I having an amino acid sequence expressed by formula I and an allergen to pollen of Chamaecyraris obtusa Cha. o. II having an amino acid sequence expressed by formula II. This allergen is useful for diagnosis, prevention or curing of an antigen-specific pollinosis of Chamaecyraris obtusa. This allergen to pollen of Chamaecyraris obtusa is obtained by extracting mRNA from pollen of Chamaecyraris obtusa in an usual method, synthesizing cDNA using the extract as a mold, producing a cDNA library, screening the library using a probe, integrating the resultant DNA of allergen to pollen of Chamaecyraris obtusa into a vector and manifesting in a host cell. |
