发明名称 |
Process for the preparation of 4-methyl-5-(2-chloroethyl)-thiazole and analogues thereof |
摘要 |
The present invention relates to a process for the preparation of compounds of general formula (I), wherein R stands for a straight chained C1-5alkyl group substituted by a chlorine atom in the 2-position, and acid addition salts thereof, characterized by reacting a 3,5-dichloro-2-alkanone of general formula (V), wherein R is a defined above, with an inorganic thiocyamate, and a) converting the 3-thiocyanato-5-chloro-2-alkanone of general formula (IV), thus obtained, wherein R is as defined above, into 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II), wherein R is as defined above, by gaseous hydrochloric acid in an organic solvent, hydrogenating the said compound in the presence of a metal catalyst in an organic solvent, or b) reacting said compound of general formula (IV) with an aqueous mineral acid and treating the 2-hydroxy-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (III), thus obtained with a halogenating agent, and hydrogenating the 2-chloro-4-methyl-5-(2-chloroalkyl)-thiazole of general formula (II) thus obtained, wherein R is as defined above, in an organic solvent in presence of a metal catalyst, and optionally converting the 4-methyl-5-(2-chloroalkyl)-thiazole of general formula (I), wherein R is as defined above, thus obtained or a hydrochloride salt thereof, in a manner known per into another acid addition salt or setting free a compound of general formula (I), wherein R is a defined above, from its acid addition salt.
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申请公布号 |
US5534644(A) |
申请公布日期 |
1996.07.09 |
申请号 |
US19950464308 |
申请日期 |
1995.06.05 |
申请人 |
AKTIEBOLAGET ASTRA |
发明人 |
PALOSI, ENDRE;KORBONITS, DEZSO;MOLNAR NEE BAKO, ERZSEBET;SZVOBODA NEE KANZEL, IDA;HEJA, GERGELY;KISS, PAL;GOENCZI, CSABA;SPERBER, FERENC;HUSZAR, CSABA;MIHALOVICS, GYOERGY;NEMETH, ATTILA;SUE , MIHALY;GYUERE, KAROL;BONE, ISTVAN;MORASZ, FERENC;LEDNICZKY, LASZLO;SZABO NEE KARDOS, ERZSEBET;GY RI, PETER;SZALAY, ERZSEBET;BAN, KAROLY;BUTTKAI, IIDIKO;K VARI, ARPAD;GARACZY, SANDOR |
分类号 |
C07D277/20;C07C331/02;C07C331/04;C07D277/22;C07D277/32;C07D277/34;(IPC1-7):C07C331/02 |
主分类号 |
C07D277/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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