Aromatic-sulfonamide-type hydroxamic acid derivative

摘要

PCT No. PCT/JP92/01593 Sec. 371 Date Aug. 3, 1993 Sec. 102(e) Date Aug. 3, 1993 PCT Filed Dec. 7, 1992 PCT Pub. No. WO91/12075 PCT Pub. Date Jun. 24, 1993.A novel hydroxamic acid compound of the formula: <IMAGE> (I) or a pharmaceutically acceptable salt thereof having cell growth inhibition, vascularization inhibition activities and the like. The compounds of the present invention possess inhibitory activities against the growth of vascular endothelial cells and the expression of lymphocyte adhesive factors and the detransforming activity of cells transformed by ras gene, and inhibit the cell growth and are effective on inflammation and tumor.