Antiviral nucleoside analogues contain a substituted benzimidazole base attached to a carbocyclic ring in place of the conventional sugar residue. Particularly preferred compounds include those in which the 2-, 5- and 6- positions of the benzimidazole base are substituted by halogen. The compounds have activity against herpes virus especially cytomegalovirus and also hepatitis B virus infections.
申请公布号
US5534535(A)
申请公布日期
1996.07.09
申请号
US19940304006
申请日期
1994.09.09
申请人
BURROUGHS WELLCOME CO.;THE REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人
TOWNSEND, LEROY B.;DRACH, JOHN C.;GOOD, STEVEN S.;DALUGE, SUSAN M.;MARTIN, MICHAEL T.