INHIBITOR OF ARTERIALIZATION

摘要

PURPOSE: To obtain an inhibitor of arterialization containing borrelidin or its salt as an active ingredient and useful for treatment, etc., of various solid cancers. CONSTITUTION: This inhibitor of arterialization contains borrelidin, having a structural formula represented by the formula and isolated as an antibiotic substance from a culture solution of a microorganism of the genus Streptomyces to determine the structure thereof or its salt as an active ingredient. The borrelidin is preferably obtained by culturing Streptomyces rochei Mer-N 7167 (FERM P-14670) in a nutrient culture medium and collecting the borrelidin from the culture solution from the viewpoint of productivity.