| 摘要 |
PURPOSE: To provide the subject new compound exhibiting excellent phosphatidylinositol 3 (PI3) kinase inhibiting action at a low concentration and useful as a PI3 kinase inhibitor expected to be usable as an antitumor agent, an anti-inflammatory agent and an antiarteriosclerotic agent. CONSTITUTION: This compound is expressed by formula I (R is H,β-D- glucopyranosyl orβ-D-galactopyranosyl), e.g. 2-(β-D-glucopyranosyloxy)-6-heptyl-4- hydroxybenzoic acid 3-heptyl-5-hydroxy-4-(methoxycarbonyl)phenyl ester. The compound of formula I can be produced by dissolving a compound of formula II in a solvent such as methanol, toluene or THF, adding excess trimethylsilyldiazomethane and leaving standing at room temperature to effect the methyl esterification reaction of the components.
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