| 摘要 |
PURPOSE: To obtain a new synthetic peptide derivative having a specific amino acid sequence, manifesting a bone-inducing factor antagonist-like activity and effective for suppressing symptoms of bone-metabolic disease accompanying ectopic ossification or calcinosis and useful for a therapeutic medicine of arteriosclerosis or ectopic ossifying disease, etc. CONSTITUTION: This new synthetic peptide derivative is expressed by the formula: P<1> -R<1> -P<2> [P<1> is a peptide having an amino acid sequence expressed by formula I or its analog; P<2> is a peptide having an amino acid sequence expressed by formula II or its analog; R<1> is a linker composed of an organic group having carboxyl groups on both ends and connectable to N-ends of peptides expressed by formula III or formula IV, etc. (R<2> is a 1-6C alkylene, a 6-9C cycloalkylalkylene or a 7-9C phenylalkylene; R<3> is H, an alkyl or an aryl, etc.)], manifesting a bone-inducing factor antagonist-like activity and effective for suppressing symptoms of bone-metabolic disease accompanying ectopic ossification or calcinosis and useful for a therapeutic or preventing medicine, etc., of arteriosclerosis or ectopic ossifying disease, etc. |
