PHOSPHOTYROSINE ASSAY AND PEPTIDES FOR USE THEREIN
摘要
This invention relates to an assay for molecules capable of interacting with cytokine receptor intracellular peptides, and to peptides suitable for use in said assay. The peptides correspond to tyrosine-containing regions of the sequence of an intracellular domain of a cytokine, a hormone receptor or a JAK Protein Tyrosine Kinase, and comprise a tyrosine which is able to be phosphorylated. In phosphorylated form, the peptides are able to bind cytoplasmic transcription factors of the STAT family.
申请公布号
WO9620211(A1)
申请公布日期
1996.07.04
申请号
WO1995US16988
申请日期
1995.12.22
申请人
LUDWIG INSTITUTE FOR CANCER RESEARCH;WILKS, ANDREW, FREDERICK;HARPUR, AILSA, GWENDOLINE;OATES, ANDREW, CHARLES;LACKMANN, MARTIN
发明人
WILKS, ANDREW, FREDERICK;HARPUR, AILSA, GWENDOLINE;OATES, ANDREW, CHARLES;LACKMANN, MARTIN