摘要 |
A cephalosporin acetylhydrolase gene, a recombinant DNA molecule prepared by introducing said gene into a vector used in an E. coli host-vector system, E. coli cells transformed with said recombinant DNA molecule, a protein having the amino acid sequence encoded by said gene, an enzyme which is a multimer of said protein, and a process for preparing said protein or enzyme are provided, said cephalosporin acetylhydrolase being an enzyme useful for converting cephalosporins such as cephalosporin C and 7-ACA into deacetylated ones such as deacetylcephalosporin C and deacetyl 7-ACA which are useful as an intermediate for preparing a variety of derivatized cephalosporin antibiotics. <IMAGE> |
申请人 |
SHIONOGI SEIYAKU K.K., OSAKA, JP |
发明人 |
MITSUSHIMA, KENJI, OSAKA-SHI, OSAKA-FU, JP;TAKIMOTO, AKIO, KOBE-SHI, HYOGO-KEN, JP;YAGI, SHIGEO, TAKATSUKI-SHI, OSAKA-FU, JP;SONOYAMA, TAKAYASU, SAKAI-SHI, OSAKA-FU, JP |