NANOFIBROUS MATERIALS AS DRUG, PROTEIN, OR GENETIC RELEASE VEHICLES

摘要

The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents front the fabric upon uptake of water from the ambient environment.

主权项

1. A method of forming a fabricated textile by electrospinning perfusion, the method comprising steps of:
dissolving a non-biodegradable polymer in a solvent to provide an admixture, the dissolving occurring at an ice-cold temperature; permitting the admixture to warm to a temperature between about 20° C. and about 50° C.; loading the admixture into an electrospinning perfusion instrument which can be set at a specified flow rate; perfusing the admixture onto a target surface at the specified flow rate, the step of perfusing occurring at a temperature between about 20° C. and about SOX to provide a perfused material; and permitting trace solvent to be removed from the perfused material to form a fabricated textile.