3-ARYL-TETRONIC ACID DERIVATIVES, THE PRODUCTION THEREOF AND THE USE THEREOF AS ANTIPARASITIC AGENTS

摘要

The invention concerns novel 3-aryl-4-hydroxy-.DELTA.3-dihydrofuranone derivatives of formula (I), wherein: A and B together with the carbon atom to which they are bound form a five to seven member ring which is interrupted by at least one heteroatom and either unsubstituted or substituted; X represents alkyl, halogen or alkoxy; Y represents hydrogen, alkyl, halogen, alkoxy or halogenated alkyl; Z represents alkyl, halogen or alkoxy; n is 0, 1, 2 or 3; G represents hydrogen (a) or one of the groups (b), (c), (d), (e), (f) or (g) shown; E represents a metal ion equivalent or an ammonium ion; L represents oxygen or sulphur; and R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in the description. The invention also concerns methods of producing the said compounds and the use of the said compounds as anti-parasitic agents, as well as intermediate products of formula (II) in which R8 represents alkyl.