PYRIMIDINE DERIVATIVES

摘要

A pyrimidine derivative represented by general formula (1) or a salt thereof and a medicine comprising the same as the active ingredient, wherein R1 represents lower alkyl; R2 and R3 represent each hydrogen, alkyl or alkoxy; R4 and R5 represent each hydrogen or alkyl; R6 represents alkyl, -OR7 or NR8N9; and n represents a number of 0 to 3 (wherein R7, R8 and R9 represent each hydrogen, alkyl, aryl, aralkyl, amino, heterocycle, etc.). The compound has a potent inhibitory activity on endothelin having potent vasoconstrictor and cell proliferation effects and is useful in treating circulatory disorders, etc.